Title: The relationship of polymorphism of MTHFR and plasma homocysteine level with Alzheimer disease
Abstract: Objective: To study the relationship of polymorphism of MTHFR and plasma homocysteine level with Alzheimer diseases. Methods: The genotyes of MTHFR were determined by PCR-based assay and their plasma homocysteine levels were determined using FPIA Method in 66 patients with Alzheimer disease and 143 healthy controls. Results:Mean total plasma homocysteine concentrations were significantly higher in AD patients than in the normal subjects. MTHFR T allele of patients obviously was higher than controls, MTHFR C alleleof patients was lower than cotrols. Conclusions: The C677T methylenetetrahydrofolate reductase mutation is associated with Alzheimer's disease,MTHFR gene and hyperhomocysteinemia may be independent risk factors for Alzheimer's disease.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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