Title: Preparation of 5-fluorouracil PLGA nanoparticles
Abstract: 5-fluorouracil nanoparticles were obtained by W/O/W-liquid drying process using biodegradable materialspoly(L-lactic-co-glycolic acid)(PLGA).In order to reach submicron size,a high pressure homogenizer to obtain nanoparticles with a high grade of monodispersity was used.The orthogonal test design was used to optimize the conditions of preparation.The shape of the nanoparticles was observed by TEM.The mean diameter and the particle size distribution of nanoparticles,the encapsulation efficiency,the drug loading,the reappearances of pharmaceutical technology were investigated.The results indicated that 5-fluorouracil PLGA nanoparticles were sphere like with the mean size of 85.4 nm,the drug loading was(12.4±0.7)%,the encapsulation efficiency of nanoparticles was(64.1±5.3)%.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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Cited By Count: 1
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