Title: Expression and its significance of VEGF in gallbladder carcinomas
Abstract: Objective To investigate the expression and its significance of vascular endothelial growth factor (VEGF) in gallbladder carcinomas. Methods The expression of VEGF and microvessel density (MVD) were detected by immunohistochemistry in 42 cases of gallbladder carcinomas.Results The expressive rate of VEGF in gallbladder carcinomas was 48%. The MVD in VEGF positive cases was significantly higher than that in negative cases (t=4.09, P0.001). The expression of VEGF was related with clinical stage (χ 2=4.55, r=0.33, P0.05) and lymph node metastasis (χ 2=7.77, r=0.43, P0.01). Conclusion VEGF is associated with MVD, clinical stage and lymph node metastasis in gallbladder carcinomas, and may be served as a prognostic factor for those patients.
Publication Year: 2001
Publication Date: 2001-01-01
Language: en
Type: article
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