Title: Study on the therapeutic effects of pioglitazone on insulin resistance in polycystic ovary syndrome
Abstract: Objective To evaluate the therapeutic effects of pioglitazone on the insulin resistance in both the whole body and endometrial situs in patients with polycystic ovary syndrome (PCOS). Methods 25 patients with PCOS plus insulin resistance were designated as the experiment group,of which 8 ovulatory cases who had received pioglitazone served as the induced ovulation group. 15 tubal infertility cases and 8 PCOS cases with spontaneous ovulation were designated as control group 1 and control group 2,respectively. The patients in the experiment group were treated with pioglitazone 15 mg twice daily for 3 months to observe the variations of serum insulin levels before and after the treatment. Endometrial samples were obtained from the induced ovulation group,control group 1 and control group 2 on the seventh day after ovulation. Immunohistochemical staining was performed to determine the expression of insulin receptor (IR). Results After the treatment,the fasting insulin and 2-hour insulin levels as well as HOMA-IR markedly decreased in the experiment group as compared to the period before the treatment. No significant differences were observed in IR between the induced ovulation group and control group 1,while compared with control group 2,the expression level of IR of epithelial cells were significantly upregulated,with no significant difference in IR expression of stromal cells. Conclusion Pioglitazone can ameliorate the insulin resistance in both whole body and endometrium of PCOS patients.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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