Title: Effect of Shenqiyixin Granule on Cardiac Function of Dogs with Experimental Heart Failure
Abstract:Objective: To study the possible effect of Shenqiyixin granule on cardiac function of experimental heart failure dogs.Methods: Acute heart failure model was esablished by intravenous injection of sodi...Objective: To study the possible effect of Shenqiyixin granule on cardiac function of experimental heart failure dogs.Methods: Acute heart failure model was esablished by intravenous injection of sodium pentobarbital.Shengmaiyin and digaoxin were used as positive control.Hemodynamic indexes of Shenqiyixin granule treated heart failure dogs were studied,which included left ventricular systolic pressure(LVSP),maximum value of change rate of left ventricular pressure(dp/dtmax),cardiac output(CO),left ventricular myocardial contractility(LVMCF),left ventricular end diastolic pressure(LVEDP),and the interval from the beginning of ventricular contraction to arriving dP/dtmax(R-dp/dtmax).Results: Intravenous injection of 2% pentobarbital sodium induced acute heart failure in dogs,manifested by the decrease of LVSP,dp/dtmax,LVMCF and CO,and by the increases of LVEDP and R-dp/dtmax.However,Shenqiyixin granules increased LVSP,dp/dtmax and LVMCF,strengthened heart contractile function,decreased R-dp/dtmax and LVEDP,and improved cardiac diastolic function.At the same time,it increased CO and RBF in acute heart failure dogs.Conclusion: Shenqiyixin granules have obvious protective effects to dogs from hemodynamic changes caused by experimental acute heat failure.Read More
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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