Title: Establishing a model of heart failure induced by pressure overload plus volume in rabbits
Abstract:Objective To establish an animal model of heart failure induced by pressure overload plus volume in rabbits. Methods Sixteen rabbits were divided into heart failure and sham-operated groups with 8 ani...Objective To establish an animal model of heart failure induced by pressure overload plus volume in rabbits. Methods Sixteen rabbits were divided into heart failure and sham-operated groups with 8 animals each. We obtained a volume overload by creation of an aortic insufficiency at first,and then obtained pressure overload induced by constricting the abdominal aorta 7 days later. The homodynamic parameters and cardiac structure and function were detected via catheterization and echocardiography respectively 7 weeks later.Results Aortic systolic pressure,pulse pressure, left ventricular end diastolic pressure of heart failure rabbits were significantly increased compared with those of sham-operated rabbits (P0.05). The left atria diameter,inter-ventricular septum,left ventricular post-wall dimension,left ventricular end diastolic and systolic diameter were also increased markedly in heart failure rabbits,but their ejection fraction and left ventricular shorten fraction were decreased(P0.05). In heart failure rabbits, the ratio of left ventricular mass and pulmonary mass to body weight were higher than that in sham-operated rabbits (P0.05). Conclusion Animal model of heart failure has been established by pressure overload plus volume overload in rabbits successfully,in which the heart failure develops with short time and higher rate of success,and is in accordance with the development of human heart failure.Read More
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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