Title: Effect of lycopene on learning and memory in rats exposed to manganese chloride
Abstract: OBJECTIVE To investigate the effects of lycopene on learning and memory in rats exposed to manganese chloride. METHODS Adult male rats were ip given manganese chloride 15 mg·kg- 1,and lycopene 5,10 and 15 mg·kg- 1for three months. The escape latency and swimming time were detected by WT-200 water maze at the end of the first,second and the third months. After three months later,the atomic absorption spectrometry method was used to determine the manganese contents in blood,liver and hippocampus. The spectrophotometry was used to determine the activities of superoxide dismutase( SOD),glutathione peroxidase( GSH-Px),catalase( CAT) and the contents of maleic dialdehyde( MDA) in liver and hippocampus. RESULTS Compared with normal control and lycopene groups,the escape latency and swimming time in Mn model group significantly increased( P 0. 05). The manganese contents in blood,liver and hippocampus markedly increased( P 0. 05). The body mass greatly decreased( P 0. 05). At the same time,Mn administration induced oxidative stress as evidenced by elevated levels of lipid peroxidation measured as MDA in liver and hippocampus tissues( P 0. 05). Moreover,the activities of SOD,GSH-Px,and CAT significantly decreased in the liver and hippocampus tissues( P 0. 05). However,the escape lantency decreased from 50. 7 ± 10. 8,46. 1 ± 9. 2 and( 51. 4 ± 13. 6) s in Mn model group to 42. 1 ± 4. 0,27. 5 ± 4. 6 and( 26. 0 ± 4. 7) s when ig given lycopene 15 mg·kg- 1at the end of the first,second and the third month,respectively( P 0. 05),the swimming time decreased from 38. 7 ± 9. 2 and( 45. 2 ± 14. 2) s to 26. 2 ± 4. 8 and( 27. 3 ± 8. 3) s( P 0. 01). The manganese contents in blood,liver and hippocampus decreased significantly( P 0. 05),the MDA contents decreased significantly in liver and hippocampus( P 0. 05),the activities of SOD,GSH-Px and CAT increased significantly in the liver and hippocampus tissues( P 0. 05). CONCLUSION Lycopene administration can improve learning and memory in rat exposed to manganese chloride,and minimize the toxic effects of manganese indicating its free radical scavenging and powerful antioxidant activities.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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