Title: Effect of Zinc on the Growth and Anti-oxidation Function of Rats
Abstract: Objective To study the effect of zinc on lipid peroxidation, anti-oxidase and development of rats. Methods 64 SD rats weight was(109.7±10.4) g, 32 male, 32 female were randomly divided into 4 groups. Every group was fed on the fodder contained zinc of different content for 40 days to build animal model. The Zn, Cu, Fe and MDA contents, SOD and GSH-Px activity in tissue of rats were determined. The One-way ANOVA test was used for multiple related samples and simple correlation analysis was used. Results Compared with 30 mg/kg group, the development of thighbones and the body weight of rats in groups with zinc exposure doses of 9 and 400 mg/kg bw were significantly retarded, the consumption rate of fodder was lower in male rats (P0.05). In both low dose and high dose groups(9 and 400 mg/kg bw), the viscera indexes increased significantly (P0.05), Cu content in the heart, serum and testis decreased significantly (P0.05), MDA in the serum and kidney increased significantly (P0.05), GSH-Px activity in the serum and heart decreased significantly (P0.05). Conclusion Both of deficiency and excessive intake of zinc may have an adverse effect on the development and anti-oxidation function of rats.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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