Title: Studies on Q-,N-type Ca2+ channel in unstable bladder of rabbit's partial bladder outlet obstruction
Abstract: Objective:To study Q-,N-type Ca2+ channel in the unstable bladder of rabbit's partial bladder outlet obstruction.Methods:Thirty male New Zealand white rabbits had been divided into 2 groups randomly, the control group(15 sham operated age-matched rabbits acted as the control group, time of postoperation for 8 weeks) and the experiment group(time of model for 8 weeks, those with unstable bladder were confirmed by Urodynamics). After the model had been finished, bladder smooth muscle cells of these rabbits were isolated by collagenase digestion. Q-,N-type Ca2+ channel changes in detrusor cell between the control group and the experiment group were observed by confocal laser scanning microscope(CLSM) and immunochemical methods. Results:There were Q-,N-type Ca2+ channels in membrane of bladder smooth muscle cell with CLSM and immunochemical method. Q-,N-type Ca2+ channels significantly increased in the unstable bladder of the experiment group. Conclusion:It was an important pathogeny for the unstable bladder of partial bladder outlet obstruction that changes of pathology and pathophysiology of Ca2+ and Ca2+ channels with the unstable bladder .
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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