Title: Conservative Surgery Combined With Mifepristone In Treatment Of Moderate Or Severe Endometriosis
Abstract: Objective To evaluate the efficiency and safety of mifepristone(Ru486)in treatment of moderate or severe endometriosis after conservative surgery.Methods Ninety women with moderate or severe endometriosis after conservative surgery were divided into three groups:mifepristone group(30 cases,mifepristone 12.5 mg/d,6months);gonadotropin releasing hormone agonist (GnRH-a) group(30 cases,hypodermically leuprorelin acetate,3.75 mg/ml,6 months);control group(30 cases)did not receive any postoperative medical treatment.Patients'symptoms and signs including pelvic pain,and pelvic tenderness were recorded before and after treat ment.Side-effects were recorded after treatment.Sex hormone levels were also examined at the same time.Results Both Ru486 and GnRH-a treament achieved similarsignificant relief of pelvic symptoms and signs(90%and 93.3%)compared with the control group(P0.01).Both the cumulative recurrence rates of Ru486 and GnRH-a groups were 6.7%,significant lower than that of the control group(P0.05).There were no significant differences between Ru486 and GnRH-a groups(P0.05).Serum estradiol(E2)level was significantly reduced in both Ru486 and GnRH-agroups,but was maintained at the level of early follicular phase in the group of Ru486(120±9)pmol/L and menopause phase level in the group of GnRH-a(62±9)pmol/L.Conclusion Ru486 seems to be an effective,safe,and convenient treatment for endometriosis with low-cost,good compliance,and few side effects.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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Cited By Count: 1
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