Title: Clinical study of effect of mifepristone and gestrinone as a subsidiary treatment after endometriosis surgery
Abstract: Objective To evaluate the efficiency and safety of mifepristone and gestrinone in subsidiary treat- ment after endometriosis surgery.Methods Totally 151 patients diagnosed as endometriosis with conservative surgery treatment or laparoscopic operation were divided into three groups;49 cases in the group of mifepristone re- ceived mifepristone tablets 10mg every day for 6 months from the first week of postoperation,60 cases in the group of gestrinone received gestrinone capsules 2.5mg twice every week for 6 months.Cases in the group of control did not receive any postoperative medical treatment.The duration of follow-up after surgery was censored at 3~18 months.Patients'controlling rate of ache symptoms and signs,clinical efficiency,recurrence rate,sex hormone level, menstrual and weight changes,liver and renal functions were recorded and compared.Results The follow up rate is 97.4 %,the efficacious rate and symptoms controlling rate of mifepristone group and gestrinone group were 78.7 %, 93.1% respectively,which of the control group were 34.8 %,58.7 % respectively.There were significant differ- ences,x~2=44.31,P0.01;the recurrence rate of mifepristone group and gestrinone group were 14.9 % and 3.4 % respectively,the control group was 32.3%,x~2=16.26,P0.01.There were significant differences between mifepristone group and gestrinone group,x~2=4.34,P0.05;serum estradiol(E_2)level of mifepristone group was significantly reduced from(209±78)pmol/L to(92±2)pmol/L,compared with before and after 6 months' medical treatment.There were significant differences,u=9.64,P0.01.Serum estradiol(E_2)level of gestrinone group was significantly reduced from(211±62)pmol/L to(75±35)pmol/L,compared with before and after 6 months' medi- cal treatment,but serum E_2 was maintained at the level of early follicular phase,there were significant differences,u =2.72,P0.01;stopping medical treatment for 6 months,both of the serum E_2 increased to the previous level. Conclusion The value gestrinone has on treatment effect and reducing recurrence rate is better than mifepristone does on endometriosis postoperative treatment,which could be considered one of the best associated treatment of en- dometriosis postoperative subsidiary treatment.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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