Title: Clinical observation of treatments of endometriosis with GnRH-a in different ways
Abstract: OBJECTIVE To discuss the best therapy option with gonadotropin-releasing hormone agonist(GnRH-a) for patients of endometriosis after conservative surgery.METHODS Choosing 148 patients after conservative laparoscopic or open surgery for endometriosis from July 2005 to December 2007 in our hospital-line,which were randomly divided into 3 groups:A(add back therapy group) 51 cases,B group(extended interval-dosing regimen group) 48 cases,C group(control group) 49 cases.Analyze and compare the situation after different treatment,concluding recurrence rate of,symptomatic relief,hormones level after treatment and drug side effects.RESULTS (1)Symptoms were relieved obviously for all patients,Symptoms were relieved completely in 45 patients of A group,42 patients of B group and 45 patients of C group.There was no significant difference between the three groups(P0.05).Two years after treatments,there was no significant difference in recurrence rate between three groups(P0.05).A group had 3 cases of recurrence,the cumulative recurrence rate was 5.88%,B group had 3 cases of recurrence,the cumulative recurrence rate was 6.25%,C group had 2 cases of recurrence,the cumulative recurrence rate was 4.08%.(2)6 months after treatments,hormone levels were significantly decreased,reaching the baseline level.The level of serum E2 of A group and B group were higher than C group,which was statistically significant(P0.05).The serum E2 levels were not significantly different between A group and B group(P0.05).(3)Incidence of side effects of A group and B group was significantly lower than C group,which was statistically significant(P0.05).(4)The bone mineral density of all patients had recovered 2 years after treatment.The bone mineral density of patients of A group had not decreased significantly 6 months after treatments.But that of B group and C group had decreased significantly.comparing with before treatment,there was statistically difference(P0.05).CONCLUSION Compared with the control group,add-back therapy and extended-interval dosing regimen did not reduce the efficacy of drug delivery,and can reduce drug side effects,but extended-interval dosing regimen did not prevent bone loss.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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