Title: EXPRESSION AND ITS CLINICAL IMPLICATIONS OF PLATELET-ENDOTHELIUM DERIVED FACTOR IN BREAST CANCER TISSUES
Abstract: Objective To observe the expression of PDGF in breast carcinoma and its correlations with angiogenesis,metastasis and prognosis.Methods PDGF and MVD was detected immunohistochemically in 60 patients with breast carcinoma.Results PDGF expressions in breast carcinoma was 65.0%.Significant correlation was found between PDGF expression and histological gradings,clinical stages,lymph node status,distant metastasis,early death (P0.05),as well as with MVD (P 0.05 ),but not with tumor size,ER,PR(P0.05).Conclusion PDGF is an important angiogeneic factor of breast carcinoma.PDGF-positive staining may be at high risk of metastasis and unfavorable prognosis.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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