Title: Expression of hypoxia-inducible factor 1 alpha(HIF-1α) and its relationship with tumor angiogenesis in human breast carcinoma
Abstract: Objective To investigate the expression of hypoxia-inducible 1 alpha (HIF-1α) in human breast cancer and its relationship to vascular endothelial growth factor (VEGF) protein,microvessel density (MVD),other tumor biomarkers and clinical pathologic factors.Methods Imunohistochemical staining (SP) was used to detect the expression of HIF-1α, VEGF in human breast fibroadenoma,usual hyperplasia and breast carcinoma.MVD was determined by anti-CD_ 34 imunostaining.Results Breast fibroadenoma and hyperplastic lesion showed no detectable HIF-1α.In contrast,increased levels of HIF-1αwere found in ductal carcinoma in situ (DCIS, 11/20) and invasive breast carcinoma.The positive expression rate of VEGF in breast carcinoma was 81.3%.The increased levels of HIF-1α were statistically significantly associated with the increased expression of VEGF (r=0.762,P0.01) and MVD in DCIS (r=0.682,P0.05),but not with MVD in invasive breast carcinoma.Conclusion The upregulation of the expression of HIF-1α and its target gene VEGF in breast carcinoma has a close relationship with tumor angiogenesis,and HIF-1α is associated with lymph node metastasis,ER status and stages of histology.These suggest that HIF-1α plays an important role in the carcinogenesis and progression of breast carcinoma.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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