Title: [The pharmacokinetics of rhein in 12 healthy volunteers after oral administration of rhubarb extract].
Abstract: To study the pharmacokinetics of rhein in 12 healthy volunteers after oral administration of rhubarb extract.The blood sample were obtained at 0,0.083,0.5,1,1.5,2,3,4,5,7,10 h after a single dose oral administration of rhubarb (50 mg x kg(-1)). The plasma rhein concentration was determined by HPLC. The pharmacokinetics of rhein were analysed by 3P97 program.The absorption of rhein was very fastafter oral administration of rhubarb extract in the healthy volunteers. The main pharmacokinetic parameters of rhein were C(max) (3.20 +/- 1.08) microg x mL(-1); t(max) (1.03 +/- 0.41) h; t(1/2alpha) (0.21 +/- 0.02) h; t(1/2beta) (2.68 +/- 1.09) h; MRT(5.31 +/- 1.78) h; AUC(0-infinity) (1 573.08 +/- 366.48) microg x mL(-1) min(-1), respectively.Rhein could be absorbed rapidly and its pharmacokinetics was consistent with two-compartment model.
Publication Year: 2005
Publication Date: 2005-09-01
Language: en
Type: article
Indexed In: ['pubmed']
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Cited By Count: 8
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