Title: The pharmacokinetics of zopicolone tablet in 10 healthy male volunteers
Abstract: OBJECTIVE To study the pharmacokinetics of zopicolone in 10 healthy male volunteers.METHODS The blood samples were obtained at 0,0.25,0.75 1.0,1.5,2.0,3.0,4.0,6.0,8.0,12,24 h after a single dose administration of 15 mg zopicolone tablet.The plasma zopicolone concentration was determined by HPLC.The pharmacokinetics of zopicolone were analysed by 3P87 program.RESULTS The main pharmacokinetic paramerers of zopicolone were K a (11.03±10.38) h -1 ,AUC 0~24 (1 049.61±286.02) ng·h·mL -1 , c max (109.35±30.89) ng·mL -1 , t max (1.32±1.24) h and t 1/2(Ke) (5.97±1.49) h,respectively.CONCLUSIONS Zopicolone could be absorbed rapidly and its pharmacokinetics was consistent with one compartment model.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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