Title: Expression of MMP-1 and TIMP-1 in DSS-induced Ulcerative Colitis in Rats
Abstract: Objective To examine expression of MMP-1 and TIMP-1 of colonic mucosa at both mRNA and protein levels in Dextransodium Sulfate(DSS)-induced ulcerative colitis(UC) in rats.Methods Male SD rats were randomly divided into model group and normal control group(12 animals each).Ulcerative colitis was induced by DSS.Reverse transcription-polymerase chain reaction(RT-PCR) and immunohistochemistry were used to study the expression of MMP-1 and TIMP-1 at both mRNA and protein levels.Results Expression of MMP-1 and TIMP-1 in the model group was significantly higher than that of controls(P0.05),with the increase of MMP-1 being more profound.Conclusion Expression of MMP-1 and the comparatively insufficient expression of TIMP-1 were related to tissue damage in DSS-induced UC in rats,and the imbalanced ratio of MMP-1 and TIMP-1 played an important role in the process of tissue damage.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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