Title: Effect of Kuijieling Decoction on Gene Expression of ICAM-1 in Colonic Mucosa of Ulcerative Colitis Rats
Abstract: Objective Gene expression of intercellular adhesion molecules(ICAM-1)in colonic mucosa of ulcerative colitis(UC)rats was observed to study the therapeutic mechanism of Kuijieling Decoction(KD). Methods UC rat models were induced by trinitrobenzenesulphonic acid(TNBS).The rats were randomly divided into six groups:normal control(NC)group,model control(MC)group,low-dose Kuijieling group,middle-dose Kuijieling group,high-dose Kuijieling group and salicylazosulfapyridine(SASP)group.After treatment for 10 days,the rats were killed to get their colonic mucosa.Total RNA was isolated from colonic mucosa by Trizol.Withβ-actin as internal index,reverse transcription polymerase chain reaction(RT-PCR)was used to detect ICAM-1 expressions.Results Gene expression level of ICAM-1 in MC group was significantly higher than that in NC group (P0.01).Gene expression level of ICAM-1 in middle-and high-dose KD groups was significantly lower than that in MC group(P0.05 or P0.01),but was similar to that in SASP group(P0.05).Conclusion KD has an inhibitory effect on gene expression of ICAM-1 in colonic mucosa of UC model rats induced by TNBS,which may be one of its anti-UC mechanisms.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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