Title: Expression of cyclin D2 and its relationship with cellular proliferation in human brain gliomas
Abstract: AIM: To study the expression of cyclin D2 in human brain gliomas and its relationship with pathological grades and cellular proliferation activity. METHODS: The expression of cyclin D2 and PCNA was detected by immunohistochemistry in 52 human brain gliomas and 8 normal brain tissues. The positive rates and the labeling indices of cyclin D2 and PCNA were counted and compared with the pathological grades of gliomas, respectively. RESULTS: Neither cyclin D2 nor PCNA was expressed in normal brain tissues. With the advancing of pathological grades, the positive rates and mean labeling indices for cyclin D2 in human brain gliomas increased accordingly. Significant difference was seen in labeling indices between grade Ⅰ, Ⅱ, Ⅲ and Ⅳ ( P 0.05) as well as between grade Ⅰ and Ⅲ ( P 0.01). Remarkable difference between low grade (grade Ⅰ and Ⅱ) and high grade (grade Ⅲ and Ⅳ) was also observed in both two indices ( P 0.05 ). Similar to cyclin D2, PCNA labeling indices increased with the malignancy grades of brain gliomas. A positive correlation was seen between the labeling indices for cyclinD2 and PCNA( r= 0.654, P 0.01). CONCLUSION: There is a positive correlation between the expression of the cyclin D2 and the cellular proliferation activity as well as pathological grades in human brain gliomas. Cyclin D2 may be involved in the progression of human brain gliomas.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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