Title: Methylenetetrahydrofolate Reductase C677T Polymorphism And Relation Ship With Coronary Artery Disease
Abstract: Methylenetetrahydrofolate reductase (MTHFR) is involved in thereduction of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. A 677 C/T single nucleotide polymorphism(SNP) localized in the MTHFR gene was associated with both thermoability and reduced activity of the enzyme and is associated withincreased homocysteine levels. The aim of this study was to establishthe genetic frequency of MTHFR SNP and whether this MTHFR SNPmay affect a homocysteine level and if it is considered as a risk factorfor Coronary artery disease (CAD).This study included 65 subjects (40 cases & 25 controls). For allparticipants in this study total lipids profile, Apo A1, homoysteine,blood glucose, folic acid and genetic polymorphism of MTHFR weredone. The percentage distribution of the different genotypes in thestudy population (all subjects) showed that the CC genotype was themost prevalent one followed by CT and then TT (45 %, 35 %, 20 %)respectively. There was no significant association of T Allele in CADgroup when compared to control group although plasma homocysteinelevel was higher in the CAD compared to the control. It seemed thatthe high levels of homocysteine in CAD are not only dependent onMTHFR activity but also on many factors such as age, sex, and othervitamins which were not measured in this study such as B12 and B6 .Key Words: Homocysteine, Folic acid, Lipid profile, Apo A1, MTHFR, Gene polymorphism, Coronary artery disease
Publication Year: 2009
Publication Date: 2009-06-03
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 3
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