Title: Effect of VEGF-D/VEGFR-3 signal pathway in the process of supraglottic carcinoma lymph metastasis
Abstract: OBJECTIVE:To investigate the control effect of VEGF-D/VEGFR-3 signal pathway during the process of lymph metastasis. METHODS: The VEGF-D/VEGFR-3 level in carcinoma tissue, para-tumor tissue and normal tissue of 50 supraglottic carcinoma patients (25N0 cases, 25N+ cases) was detected with reverse transcription polymerase chain reaction (RT-PCR), then analyze the law. RESULTS: In lymph metastasis group, the levels of VEGF-D and VEGFR-3 are 2.070±0.074, 2.022±0.061 in carcinoma area, 1.129±0.067, 1.131±0.068 in para-tumor area, 0.450±0.048, 0.478±0.064 in normal area respectively. In non-lymph metastasis group, the levels of VEGF-D and VEGFR-3 are 1.327±0.060, 1.328± 0.054 in carcinoma area, 0.927±0.052, 0.917± 0.061 in para-tumor area, 0.385±0.033, 0.335± 0.040 in normal area respectively. In the 2 groups, The highest level of VEGF-D and VEGFR-3 is carcinoma tissue, then is para-tumor, then is normal tissue; the differences are significant, t≥5.651,P0.001. The differences of VEGF-D and VEGFR-3 level in carcinoma and para-tumor areas between the 2 groups are significant, t≥2.388,P0.05; in normal tissue are insignificant, t≤1.873,P0.05. CONCLUSIOS: The VEGF-D/VEGFR-3 signal pathway is correlated with supraglottic carcinoma lymph metastasis. Their high expression in carcinoma and para-tumor may predict supraglottic carcinoma lymph metastasis. The pathway may become a new target of preventing and treating supraglottic carcinoma lymph metastasis.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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