Title: Clinical study of citalopram combined with low dose quetiapine in treatment of somatoform pain disorders
Abstract: Objective: To explore efficacy and safety of citalopram combined with low dose quetiapine in treatment of somatoform pain disorders. Methods: Eighty-one patients with the somatoform pain disorders were randomly divided into study group( 41 cases) and control group( 40 cases),wherein the cases were treated with citalopram combined with low dose quetiapine and citalopram for 6 weeks,respectively. The efficacy was evaluated by Hamilton depressive scale( HAMD) and medical outcomes study pain measurement( MOSPM) before and week 1,2,4 and 6 weeks after the treatment. The side effects were assessed by treatment emergent symptom scale( TESS) 1,2,4 and 6 weeks after the treatment. Results: After the treatment,the scores of HAMD and MOSPM of study group decreased significantly 1 week after the treatment( P0. 05),whereas those of control group decreased 2 weeks after the treatment( P0. 05). 6 weeks after the treatment,the whole curative effects of study group were better than those of control group( P 0. 05). There was no significant difference in TESS scores between the two groups. Conclusions: Compared with citalopram,citalopram combined with quetiapine in the treatment of somatoform pain disorders is more effective and has high safety and good compliance.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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