Title: HSP 70 :a possible protective agent to keep myocardial cell from apoptosis in rats
Abstract: ObjectiveTo investigate the relationship bet ween heat-shock protein 70(HSP 70 ) in ischemic myocardial cell and the p rotection of HSP 70 .MethodsMyocardial cell was cultured in vitro. HSP70 was induced by heating the incubated cells at 42℃ for 2 hours. H 2O 2 wa s used to induce injure in myocardial cells of different groups. Flow cytometry, DNA Ladder and other biochemistry methods were employed to observe the myocardi al cell of different groups.ResultsThe up-regulation of HSP 70 was detected by immunohistochemistry. The activity of cytochrome C in injured and protected groups was obviously different.ConclusionsHSP 70 could probably delay apoptosis and protect myocardial cell.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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