Title: Change of serum levels of sex hormone and clinical significance in the male patients with hepatocirrhosis in the stage of decompensation
Abstract: Objective: To explore the relationship between serum levels of sex hormone. and severity of liver dysfunction in the male patients with cirrhosis in the stage of decompensation.Methods: Serum components of sex hormone, testosterone(T), Estrone(E 1), Estradiol(E 2), and estriol(E 3) were measured by radioimmunoassay in 45 cases (14Child-pugh class A, 19Child-pugh class B, 12Child-pugh class C) decompensated cirrhosis,then compared with 20 cases normal subjects. Results: In cirrhosis group, the serum T level was significantly lower than contronl group(P0.01),E 1(P0.01) ,E 3(P0.05) were significantly higer than control group. No difference was found in serum E 2 level between two groups (P0.05). T levels progressively and significantly decreased from cirrhosis Child A to C.E1 levels progressively and significantly increased from cirrhosis Child A to C.Child-pugh score was correlated positively with E 1 (r=0.511,P0.01)and was correlated negatively with T(r=- 0.53,P0.01)in cirrhosis group. Not correlated with E 2, E 3. 32 patients of 45 cirrhosis have femi-nation,E 1 levels significantly higher in cirrhotic patients with feminization(P0.05) than without feminization. Conclusion: Hepatocirrhosis hadvarying amounts ofdisorder in levels of sex hormone in serum, depending on liver function lesion gravity, the determination of above hormone could be deserved as a standard for clinical state of illness.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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