Title: The relationship between plasma homocysteine level and stroke
Abstract: Objective To study the relationship between the level of plasma Homocysteine (Hcy) as well as its metabolism- related factors and the traditional risk factors of stroke. Methods 200 stroke patients (100 patients with cerebral infarction, 100 patients with cerebral haemorrhage) were studied, while 80 subjects without stroke as the control group. Plasma Hcy level was measured using high performance liquid chromatography. Simultaneously serum folic acid, vitamin B12, total cholesterol, blood glucose and blood pressure were measured. Results ① The level of Hcy in cerebral infarction group [(17.6 ± 5.1)μmol/L] was significantly higher than that of the control group [(11.5 ± 3.2) μmol/L] (P 0.01), but no significant difference between the infarction group and cerebral haemorrhage group(P 0.05). ②The plasma folic acid level and vitamin B12 level showed negative correlation with the plasma Hcy level in both study and control groups. ③ Hcy level was not associated with blood pressure, blood glucose, total cholesterol and triglyceride level. ④If the plasma Hcy level was higher than 15.0μmol/L, after adjusted by multy-factors, the odds ratio (OR) in cerebral infarction group was 4.64[95% creditable interzone (CI) was 2.84~8.36], the OR was 3.62(95% CI was 1.65~6.28) in haemorrhage group. Conclusion ① The increased plasma Hcy level is a independent risk factor for stroke. It is not related to the other traditional risk factors and the type of stroke. ②The level of folic acid and vitamin B12 are the non-genitic factors which affect the level of plasma Hcy in human being.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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