Title: MODULATING EFFECTS OF Tα_1 IN ASTHMATIC PATIENTS
Abstract: Objective To observe the changes of IL-12 and IL-13 levels in peripheral blood and the effects of Thymosin-α1(Tα1) on them. Methods Tα1(1 mg/kg),every other day,was given hypodermically,for 1.5 months,to 25 patients with asthma in remission.The serum IL-12 and IL-13 were measured by ELISA before and after treatment.The results were compared with 15 healthy controls. Results IL-13 levels of the patients before treatment were significantly higher than that of the controls(t=3.46,P0.01),and lower after treatment(t=8.03,P0.01).IL-12 levels of the patients before treatment were significantly lower than that of the controls(t=4.87,P0.01),and higher after treatment(t=4.75,P0.01). Conclusion Overproduction of IL-13 and underproduction of IL-12 are seen in asthma,the imbalance of IL-12/IL-13 is a key factor of asthmatic attack.Tα1 can downregulate IL-13 level and upregulate IL-12,and educes its anti-asthma through modulating IL-12/IL-13 unbalance.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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