Title: Synthesis and Antifungal Activity of Trimethylolpropane Trisalicylate
Abstract: Under the protection of nitrogen,trimethylolpropane trisalicylate was synthesized by the direct esterification process when trimethylolpropane and salicylic acid were used as reactants.The product was analyzed by IR,LC,1HNMR,MS.The structure of the target product was confirmed.The influencing factors,such as temperature,catalyst,molar ratio of salicylic acid to trimethyololpropane as well as reaction time were investigated.The optimum reaction conditions were obtained as follows:tosic acid as catalyst,which accounted for 4% of the salicylic acid,molar ratio of the carboxyl of salicylic acid to the hydroxy of trimethyolpropane 1:0.7,reacting in N2 for 6 h at 160 ℃.Under the optimum conditions the conversion of the product reached 99.5%,the yield of the trimethylolpropane trisalicylate reached 83.59%.The anti-bacterial properties of the esters were also investigated.The anti-bacterial power occurred to Escherichia Col,80% inhibitory rate occurred to either with a mass concentration of 0.01 g/mL.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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