Title: Synthesis and Antimicrobial Activity of Ionic Trans-but-2-enedioic Acid Monomethyl Ester
Abstract: The reaction conditions between maleic anhydride and methanol were optimized for synthesizing trans-but-2-enedioic acid monomethyl ester (MMF). The results showed that the optimal reaction conditions are as follows: after reaction between maleic anhydride and methanol (molar ratio 1.1:1) at 60℃ for 1 hour,adding 10.9% of aluminium chloride into the product and then maintaining the mixture at 80℃ for 2 hours. After 2 hours,71.9% yield of MMF can be obtained. Ionic trans-but-2-enedioic acid monomethyl ester was prepared through neutralization of imidazolium hydroxide with trans-but-2-enedioic acid monomethyl ester. The product was identified using FTIR and NMR. The antimicrobial activities of ionic MMF against bacteria,mold and yeast were determined by photoelectricity turbidimetric method spread plate method. It was found that ionic MMF has strong antibacterial activity and could be used as bacteriostatic agent.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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