Title: Conformal Radiotherapy Combined with Concurrent Chemotherapy for Treatment of Pelvic Recurrence Cervical Cancer after Radiotherapy
Abstract: Objective:To evaluate the curative effect and side effect of three-dimensional conformal radiotherapy (3D-CRT) combined with concurrent chemotherapy on pelvic recurrence of cervical cancer after radiotherapy.Methods:23 patients with pelvic recurrence of cervical cancer after radiotherapy from June 2006 to December 2009 as study group were treated by three-dimensional conformal radiotherapy combined with concurrent chemotherapy with a total dose of 40~60Gy in pelvic external exposure.The other 29 matched patients treated by anterior posterior field radiotherapy combined with concurrent chemotherapy with a total dose of 20~30Gy in pelvic external exposure at the same time was control group.Preliminary outcome and toxicity were evaluated in two groups.Results:1-year-survival rate was 82.6% in study group.The total efficiency rate (CR+PR) was 87.0%.The remission rates of lumbosacral pain,inferior extremity pain and leg edema were 75.0%,82.4% and 85.7% respectively.There was significant differences between two groups (P0.05).The incidence of radiation proctitis and radioactive bladder damage was 17.4% and 4.3% respectively,which was significantly statistical difference(P0.05).There was no significant difference in bone marrow inhibition between two groups(P0.05).All patients were tolerated.Conclusions:The curative effect of 3D-CRT combined with concurrent chemotherapy is better than anterior posterior field radiotherapy in the treatment of pelvic recurrence of cervical cancer after radiotherapy and the side effects are not increased.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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