Title: Effect of carvedilol and atrovastatin on vascular endothelium function in patients with coronary heart disease and chronic heart failure
Abstract: Objectives To investigate the effects of carvedilol combined with atrovastatin on vascular endothelium and left ventricular functions in patients with coronary heart disease and chronic heart failure(CHF).Methods Sixty patients with coronary heart disease and CHF were divided into CHF group(n=16), carvedilol group(n=22) and carvedilol and atrovastatin group(n=22).All patients were treated with routine anti-CHF therapy for 12-weeks, while patients in carvedilol group and in carvedilol and atrovastatin group were additionally treated with carvedilol or with carvedilol and atrovastatin respectively.Left ventricular end-diastolic dimension(LVEDd) , left ventricular end-systolic dimension(LVEDs) , left ventricular ejection fraction(LVEF) and brachial artery flow-mediated vasodilation(FMD) were detected before and after 12-week treatment.Results FMDs were higher after treatment for 12 weeks than those before treatment in all patients, besides more significance was seen in carvedilol and atrovastatin group(P 0.05);More improvement in LVEDd, LVEDs and LVEF after treatment were found in carvedilol group(P0.05) and in carvedilol and atrovastatin group(P 0.01).Conclusions Carvedilol improves the endothelium and heart functions and reduces cardiac chamber dimension in patients with coronary heart disease and CHF.The effects are more obvious with additional atrovastatin.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot