Title: The effects of Carvedilol therapy on the left ventricular remodeling and function in the patients of ischemic heart disease with cardiac dysfunction
Abstract: Objective To investigate the cardiac function improvement and ventricular remodeling with Carvedilol therapy in the patients of ischemic heart disease with heart failure. Methods 77 patients of ischemic heart disease with heart failure, i.e, ventricular ejection fraction (VEF) ≤45%, cardiac function (NYHA) Class Ⅱ~Ⅳ, were divided into the therapeutic group (received traditional therapy plus Carvedil) and the control group (received traditional therapy). After 6-month treatment, the color heart ultrasonograph was used to measure the ventricular structure and the changes of cardiac function indexes before and after treatment. Results The mean dose of Carvedilol was (24.6±11.3mg/d). After 6-month treatment, in comparison to the control group, the symptom and cardiac function improved in the therapeutic group: VEF increased [(48.5±2.4)% VS (38.9±2.61)%, P=0.02], left ventricular end-systolic volume (LVESV) decreased [(163.70±45.30)ml VS (181.50±43.80)ml, P=0.043]. In the therapeutic group (subdivided into Group Ⅱ,Ⅲ and Ⅳ, according to NYHA), comparing to pre-treatment: LVESV decreased (P0.05); but there was no statistically significant difference between groups. Conclusions Based on the medication of oral digitalis, diuretics and angiotension-converting enzyme inhibitors, carvedilol therapy can improve left ventricular performance, reverse LV remodeling in patients of coronary heart disease with heart failure and also improve the biological properties of the chronically failing heart.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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