Title: Expressions of E-cadherin,β-catenin and Cyclin D1 in renal clear cell carcinoma
Abstract:OBJECTIVE:To investigate the expression and significance of E-cadherin,β-catenin and Cyclin D1 in renal clear cell carcinoma(RCCC).METHODS:The Expression of E-cadherin,β-catenin and Cyclin D1 in 67 ca...OBJECTIVE:To investigate the expression and significance of E-cadherin,β-catenin and Cyclin D1 in renal clear cell carcinoma(RCCC).METHODS:The Expression of E-cadherin,β-catenin and Cyclin D1 in 67 cases of RCCC was detected by immunohistochemistry.The relation between the expressions and prognosis was analyzed.RESULTS:Positive rates of E-cadherin and Cyclin D1 were 35.8%(24/67) and 44.8%(30/67) in RCCC respectively.Membrane and cytoplasm positive rates of β-catenin were 23.9%(16/67) and 68.7%(46/67) respectively.The expression of E-cadherin was correlated with tumor pathologic grading and clinical staging(r=0.393,P=0.001;r=0.365,P=0.002).The expression rate of E-cadherin was correlated with that of β-catenin in membrane(r=0.531,P=0.000).The membrane expression of β-catenin was correlated with tumor clinical staging(r=0.386,P=0.001).The expression rate of Cyclin D1 was correlated with that of β-catenin in membrane(r=0.481,P=0.000).The expression rate of Cyclin D1 was correlated with tumor size(r=0.325,P=0.007).CONCLUSIONS:The results suggest a significant relationship between E-cadherin,β-catenin protein low expression or abnormal expression of RCCC and tumor pathologic grading or clinical staging.E-cadherin,β-catenin may be a useful prognostic indicator in RCCC.Read More
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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Cited By Count: 1
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