Title: Effect of several methods without penetration enhancer in transdermal permeation of flurbiprofen
Abstract: Objective To study the effect of several methods without penetration enhancer in transdermal permeation of flurbiprofen.Methods The concentration of flurbiprofen was increased and the monoethanolamine salt,sodium salt and hydroxypropyl-β-cyclodextrin inclusion complex of flurbiprofen were prepared to promote the transdermal permeation of flurbiprofen.Results When the drug concentration was less than 2%(w),the flux of flurbiprofen was increased with the increase of the concentration of flurbiprofen.The flux of flurbiprofen decreased with the increase of hydroxypropyl-β-cyclodextrin concentration.The flux of flurbiprofen monoethanolamine salt was slightly higher than that of flurbiprofen,and the flux of flurbiprofen sodium was much lower than that of flurbiprofen.Conclusions The transdermal permeation of flurbiprofen is increased by the increase of drug concentration and preparation of the monoethanolamine salt of flurbiprofen;the transdermal permeation of flurbiprofen is inhibited through the preparation of the sodium salt and hydroxypropyl-β-cyclodextrin inclusion complex of flurbiprofen.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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