Title: Study on percutaneous effect of transdermal enhancers upon transdermal absorption of Oxaprozin through mice skin
Abstract: OBJECTIVE To observe the effects of several transdermal enhancers on the permeation of oxaprozin. METHODS Using modified Franz-type vertical diffusion cells and isolated mice skin in vitro as transdermal barrier, the transdermal amout and permeation rate of oxaprozin in different concentrations and different compositions were caculated. RESULTS Several enhancers exhibited different effects, the order of effect was OAAZMT, the effect of mixed transdermal enhancers were prior to that of separate enhancers to different extent. PG inhibited the permeation obviously, and combination with OA?AZ?MT respectively were shown to have inhibitative effect. CONCLUSIONS The results showed that the percutaneous absorption of Oxaprozin was a zero-order releasing kinetics through nonpolar channel, and 10% oleic acid plus 1% azone was the most effective one.
Publication Year: 2001
Publication Date: 2001-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot