Title: A comparison of ultrasonography and pathology local injection treatment for hepatic trauma
Abstract: ObjectiveTo obtain the tissue repair form of hepatic trauma after local injection treatment and corresponding ultrasonography and contrast-enhanced ultrasonographic(CEUS)features,by comparative study between ultrasonography,CEUS and pathology different stages.MethodsEighteen NIH mice were randomly divided into three groups after local injection of thrombin and α-cyanoacrylate to treat hepatic trauma.Three groups were underwent conventional ultrasonography,CEUS and were sacrificed to get tissue pathology at 1 week,1 month,3 months after treatment,respectively.ResultsAfter treatment,the echo intensity of routine ultrasound gradually increased at the treatment area,it was heterogeneous hypoechoic after one week;local uneven hyperechoic with punctate hyperechoic after one month,patchy hyperechoic with acoustic shadow after three months.CEUS showed injury region as low or non-enhanced area,and gradually became smaller over time.Histopathology showed vasodilatation,congestion in hepatic portal area,white blood cells and lymphocytes around blood vessels and bile ducts after one week,fibroplasia,bile duct hyperplasia and fibrosis could be seen in hepatic portal area over time,after three months,lymphocytes, paddle cells,eosinophils,and calcification could be seen in injury region.ConclusionAfter local injection of thrombin and α-cyanoacrylate for hepatic trauma,inflammatory scar repair in trauma area,echo strength in ultrasonography is positively correlated with local fibrosis and calcification,ultrasonography can be used as preliminary evaluation.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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