Title: Pharmacokinetics of probucol self-microemulsifying drug delivery system in rats
Abstract: Objective:To investigate the pharmacokinetics of probucol(PB)self-microemulsifying drug delivery system(PB-SMEDDS) in rats.Methods:Rats were used as the models.With PB suspension as control,double cycle crossover with single oral dose was performed to investigate the pharmacokinetics of PB-SMEDDS.The HPLC method was established to detect drug concentration in the rat plasma,and the obtained data were processed with 3P97 software.Results:The plasma concentration-time profiles of PB-SMEDDS conformed to a two-compartment model(the coefficient weight is 1/C2).Cmax,tmax and AUC0~96h were 6.72μg/ml,8.58 h and 253.98(μg.h)/ml,respectively.The AUC0~96h of PB-SMEDDS was 19.08 times of PB suspension.Conclusion:PB-SMEDDS could improve the oral bioavailability of PB significantly.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot