Title: Pharmacokinetics and Tissue Distribution of Docetaxel Self-microemulsifying Drug Delivery System for Injection in Rats
Abstract: Objective To determine the plasma concentrations of docetaxel(12.5 mg/kg) self-microemulsifying drug delivery system and injection form the market after injected in caudal vein of rats,and to compare the pharmacokinetic behavior of the 2 groups.To determine the distribution of docetaxel in heart,liver,spleen,lung,and kidney of rats.Methods The concentration of docetaxel in plasma and tissues were tested by HPLC after a single does injection at various time points.Results There was no significant difference(P0.05) of main pharmacokinetic parameters t1/2β,CL,AUC0→∞,MRT0→∞ between 2 groups,except apparent volume of distribution(V1/F).Conclusion The self-microemulsifying and the commercial preparations of docetaxel have similar kinetic characteristics,and has no significant improvement for the tissue distribution in rats.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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