Title: Study on Pharmacokinetics of Self-microemulsifying Drug Delivery System of Ginkgo Biloba Extract 50
Abstract: Objective To study pharmacokinetics and relative bioavailability of self-microemulsifying drug delivery system of Ginkgo Biloba extract 50(GBE50-SMEDDS).Methods Using Xingling Granule as reference,morin as internal standard,and with quercetin,kaempferol and isorhamnetin as the reference substance,we calculated the content of total flavonol glycosides and detected plasma concentration of the drug in rats after intragastric administration.Results Plasma concentration-time curves and pharmacokinetic parameters showed that Cmax of GBE50-SMEDDS increased by 0.3 mg/L,Tmax was 2.7 h earlier than the reference group,the elimination of rate decreased,the elimination half-life prolonged by 7.4 h,the distribution rate was increased,the distribution of half-life was 2.2 h ahead,AUC(0-∞ increased by 13.8 mg·h/L,and relative bioavailability was 152.47 % of the reference(increasing by 52.47 %).Conclusion New formulations of GBE50 based on SMEDDS have higher bioavailability than the present Xingling Granule in the market,which will provide experimental basis for clinical efficacy improvement.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
Access and Citation
Cited By Count: 2
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot