Title: Relationship between expressions of Survivin and VEGF in colorectal carcinoma and their clinicopathologic features
Abstract: OBJECTIVE: To explore the relationship between the expressions of apoptosis suppression gene Survivin and vascular endothelial growth factor(VEGF) in colorectal carcinoma and their clinicopathologic features,and their role in the development and progression of colorectal carcinoma.METHODES: The expressions of Survivin and VEGF were assayed by immunohistochemical staining(SP) in 61 cases of colorectal carcinoma and their non-carcinomatous ends of cut specimens.RESULTS: The normal colorectal tissues were negative for Survivin,but the positive expression in 45 cases(73.77%) of colorectal carcinoma tissues.The expression of VEGF in 42 cases(68.85%) of colorectal carcinoma was positive,but no expression in normal colorectal tissues.The expressions of Survivin and VEGF in colorectal carcinoma were correlated closely with the extent of tumor invasive,Duke stages and lymph node metastasis,P0.05.CONCLUSION: Survivin and VEGF are involved in the regulation of angiogenesis in colorectal carcinoma,and correlated closely with the development,progression and prognosis of colorectal carcinoma.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot