Title: Pathological Study of PNS in Regulating Cathepsin B Expression in Rabbits with Pulmonary Fibrosis of Pulmonary Heart Disease
Abstract: Objective To investigate the effect of PNS in regulating the expression of Cathepsin B in rabbits with pulmonary fibrosis of pulmonary heart disease from the perspective of pathology.Methods Forty healthy Japanese rabbits were randomly divided into five groups(eight rabbits in each group):the control group,the PF model group,the PNS prevention group,treatment group and the western medicine treatment group.The expression of CB protein and the pathological structural changes in lung tissue were observed under light microscope.Results Compared with the model group,PNS significantly reduced the pulmonary edema,reducing pulmonary interstitial,pulmonary arteries and alveolar wall fibrosis,significantly reduced pulmonary edema fluid and inflammatory cell exudate,reducing CB protein in lung tissue expression of rabbits in the prevention group.PNS treatment group and western medicine treatment group also had effects,but the effects were significantly less than the PNS prevention group.Conclusions PNS can significantly improve the extent of pulmonary fibrosis,reduce the CB protein levels in bronchial epithelial cells,alveolar epithelial cells,reduce the inducing factors of pulmonary interstitial fibrosis,pulmonary arterioles and alveolar wall's pathological damage,in rabbits with pulmonary heart disease.Therefore,PNS can protect lung of rabbits with pulmonary heart disease against damage.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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