Title: Effect of Feikang Granules on Airway Remodeling and Transforming Growth Factor β_1 in Chronic Obstructive Pulmonary Disease Rats
Abstract: Objective To investigate the effect of Feikang Granules(FG) on airway remodeling and the transforming growth factor β1(TGF-β1) in chronic obstructive pulmonary disease(COPD)rats.Methods Forty clean SD rats were randomly divided into four groups:normal control group,COPD model group,low-and high-dose FG groups(13 and 3.25g·kg-1·d-1)respectively,10 rats in each group.Rat models of COPD with deficiency of both lung and spleen were established by the methods of cigarettes smoking,repeated infusion of lipopolysaccharide into the airway and gastric gavage of decoction of Folium Sennae.The pathomorphological changes of the rats lung tissue were observed and the small airway wall thickness was measured under the optical microscope.TGF-β1 expression in lung tissue,pulmonary alveolar macrophage,and tracheal mucosal epithelium was detected by the immunohistochemical method and the image analysis.Results The small airway wall thickness and TGF-β1 expression in bronchopulmonary tissues of the model control group differed from those in the normal control group(P0.05).There existed significant differences of the above changes between the model group and FG groups(P0.05).However,the difference of TGF-β1 expression in bronchopulmonary tissues of high-and low-dose FG groups was insignificant(P0.05).Chronic inflammatory changes and structural damage of rats airway and lung tissue were shown in the model group,and the above changes were much improved in FG groups.Conclusion The therapeutic mechanisms of FG for the treatment of COPD is probably related with the improvement of rats airway remodeling and reduction of the TGF-β1 expression to some extent.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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