Title: Experimentul study of hepatocyte growth factor in repairing articular cartilagc defects
Abstract: Objective To investigate the mechanism of hepatocyte growth factor(HGF) in articular cartilage defect repair in vivo. Methods Cylindrical, full-thick articular cartilage defects, 3. 5 mm in diameter, were produced in the knee joints of 25 rabbits. 1μg HGF dissolved in 0.1 ml saline was injected into the right knee joints 3 times a week for 4 weeks and 0. 1 ml normal saline was injected into the left knee joints as a control. The animals w ere killed respectively in 4, 6, 8, 12, 24 weeks, and the macroscopic, histologic and ultrastructural examinations were performed. Results The repairing process in experimental group was faster and hetter than that in the control. The histological and ultrastructural examination showed features of hyaline cartilage, whereas fibrous tissue was seen in the control group. The data of histological grades showed significant statistical difference (P 0.01 ). Conclusion HGF plays an important role in cartilage metabolism and it can effectively facilitate the repair of articular cartilage defect, and provides a new non-traumatic method for the treatment of articular cartilage defects.
Publication Year: 2000
Publication Date: 2000-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot