Title: Experimental study on effects of sodium hyaluronate and bFGF on repairing full-thickness articular cartilage defects of the rabbits' knees
Abstract: Objective To study the availability to repair full-thickness articular cartilage defects of the rabbits’ knees with exogenous basic fibroblast growth factor(bFGF) and sodium hyaluronate(SHb)y intraarticular injection.Methods Preparing animal models of full-thickness articular cartilage defects with same method,20 adult rabbits(40 examples) were divided into 4 groups:(1) bFGF+SH;(2) bFGF;(3) SH;(4) control group,then,the postoperative intraarticular injection of sampled specimens were given in the 3rd,4th,5th,6th and 7th week,respectively,then gave them optical microscopical and macroscopical research in 12th week,and analyzed the experimental data with statistical methods.Results Macroscopical research: The 1st and 2nd group could repair the defects better than the 3rd and 4th group,further,the 1st group was better than the 2nd group(P 0.01).Optical microscopical research: The 1st group was better than the 2nd,3rd and 4th group,and the P of every two groups was smaller than 0.01.Conclusion Exogenous bFGF has significant effects of improving cell proliferation and differentiation in repairing of full-thickness articular cartilage defects.SH associated with exogenous bFGF has more significant effects in repairing of full-thickness articular cartilage defects,and they have synergistic effects.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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