Title: Pathological Influence of Jintiange Capsule on Osteoarthritis in Rats
Abstract: Objective:To observe influence of Jintiange capsules(JC)on articular cartilage lesions and osteoarthritis induced by papain in rats.Method:Adult male SD rats were divided into sham operated group,model group,Xianling Gubao(XG)group(0.80 g·kg-1),JC high,medium and low(0.96,0.48,0.24 g ·kg-1)dose groups.The bilateral knee joint cavities were injected with papain 20 μL to induce osteoarthritis.Three weeks after the establishment of the models,different drugs were lavaged for 4 weeks.Then the rats were sacrificed and the knee joint cartilage was collected.Pathological section and microscopic observation were carried out for evaluating joint cartilage lesions.Result:Articular cartilage in model group showed thin rough surface,fiber fracture,tide line disappear,cell arrangement disorder,cell clusters,part of the joint synovial hyperplasia and finger-shaped bulge towards the joint cavity.JC of 3 doses showed different degree of alleviation for the pathological changes.Conclusion:JC can repair the damage of cartilage surface of articular cartilage with protective role.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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