Title: Influence of curcumin(姜黄素) on the expression of nuclear factor-κB in the aorta of rabbits with atherosclerosis
Abstract: Objective: To investigate the effect of curcumin(姜黄素) on the expression of nuclear factor-κB(NFκB) in the aorta of rabbits with atherosclerosis(AS).Methods: Thirty male Japanese white rabbits were fed with a highcholesterol diet for 2 consecutive months.Finally,20 rabbits of AS model were established.They were randomly divided into two groups: the control group and treatment group(each n=10).Both groups were fed with a standard diet for next 1 month.Additionally,the treatment group received an oral curcumin at a dose of 200 mg/kg body weight,and the control group received an oral curcumin-free equal volume of normal saline solution daily during the experiment.Before and after the curcumin therapeutic period,the blood samples were collected in both groups.Plasma was separated and used for the assessment of total cholesterol(TC),low density lipoprotein-cholesterol(LDL-C),high density lipoprotein-cholesterol(HDL-C) and triglyceride(TG).After treatment,all animals were killed.Entire aortas were rapidly dissected out,and the ratio of lipid plaque area was examined.The aortic arch was selected for histological examinations,and the positive expression of NF-κB in the aorta was examined with semiquantitative analysis of immunohistochemistry.Results: Finally,each of the two groups had eight rabbits in the analysis.The animals fed with high-cholesterol diet had resulted in marked hypercholesterolemia.After treatment for 1 month,compared with the control group,the TG in the treatment group was decreased by 23.5%(P=0.024),TC by 21.6%(P=0.020) and LDL-C by 30.3%(P=0.009),and HDLC was significantly increased by 16.3%(P=0.040).The ratio of lipid plaque area reduced obviously in treatment group as compared to that of control group(P=0.025).The rate of positive cell of NF-κB immunohistochemistry expression was significantly lower in treatment group than that in control group(P=0.005).Conclusion: Curcumin can decrease the expression of NF-κB in the aorta and attenuate AS development in rabbits.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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