Title: Observation of biochemical markers of Ningxintong Granules in interfering atherosclerosis vulnerable plaques in rabbit model
Abstract: Objective To investigate the effect of Ningxintong Ggranules(NXTG) on stabilizing the atherosclerosis vulnerable plaques in rabbit model.Methods 42 healthy new Zealand white rabbits were randomized into the group A,B1,B2,B3 and B4.The group A(n=6) was fed with standard chow,then underwent the balloon-induced damage 2 weeks later,and transfected byexogenous p53 gene.The group B1(n=9),B2(n=9),B3(n=9) and B4(n=9) were fed with the high cholesterol diet for 2 weeks,then underwent the balloon-induced abdominal aortic wall injury.At the end of 8 weeks,recombinant adenovirus carrying the p53 gene was injected through a catheter into the aortic segments rich in group B.After 2 weeks,all of the remaining rabbits in the group B underwent pharmacological triggering with injection of Chinese Russell′s viper venom(CRVV) and histamine.At 3 weeks,the group B1 was treated with high dose of NXTG,the B2 group with normal dose of NXTG,the group B3 with Xuezhikang and the group B4 was as the baseline control group.At the beginning of the experiment and 12 weeks,blood samples were collected for measuring the lipid profile,which including TC,TG,LDL-C,HDL-C,LDL-C/HDL-C,TG/HDL-C and TC/HDL-C.Results After 12-week high lipid diet,compared with the group A,the serum lipid levels(TC,TG,LDL-C and HDL-C) in the group B1,B2,B3 and B4 were significantly increased(P0.05).Compared with the group B4,the levels of TC,TG and LDL-C in the group B1 were decreased significantly(P0.05).Compared with group B4,the levels of TC,LDL-C and HDL-C in the group B3 were decreased significantly(P0.05),there were no significant differences in TC,TG,LDL-C and HDL-C between group B1 and B3.Compared with the group B2,the TC level in the group B1 was decreased significantly(P0.05).Conclusion NXTG has effects leading to stabilize the vulnerable plaques in rabbit model.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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