Title: The study of correlation between diabetic nephropathy and cystatin C
Abstract: Objective To explore the correlation between diabetic nephropathy and cystatin C.Methods 515 diabetes hospitalized in Henan Province People's Hospital on March 2011 to February 2012,were divided into normal albuminuria group,microalbuminuria group and macroalbuminuria group,and the cystatin C(Cys C)、microalbuminuria(mAlb)、serum creatinine(Scr),endogenous creatinine clearance rate(CG-Ccr) and other clinical parameters were compared.Results From normal albuminuria period to microalbuminuria period to macroalbuminuria period,Cys C,mAlb and Scr were increasing gradually(P 0.05),but Cys C and mAlb increased earlier than Scr;CG-Ccr decreased gradually(P 0.05).In discriminating ACR,while with a cut-off value of 30 mg/g and 300 mg/g,the area under the curve was 0.734 and 0.781 for serum cystatinC respectively(P 0.01),revealing a good diagnostic efficiency.Conclusion Cys C can evaluate glomerular filtration rate of early diabetic nephropathy more sensitively than Scr.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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