Title: Comparison the effects of letrozole and clomiphene citrate on the endocrinological profile in women with polycystic ovarian syndrome
Abstract: Objective To compare the clinical effects and endocrinological environment between letrozole and clomiphene citrate(CC) stimulated cycles in women with polycystic ovarian syndrome(PCOS).Methods A prospective,case-control study was conducted.Infertile women with PCOS were given letrozole 2.5 mg per day or CC 50 mg per day for five days.Timed intercourse or intrauterine insemination(IUI) was performed on the day of follicles rupture.Results Both ovulation rate and pregnancy rate were not different between two groups.Letrozole group had less mature follicles.Thicker endometriums and lower E2 levels were seen in the letrozole group.Androstenedione was significantly higher in the letrozole group on the cycle day 8.Conclusion Letrozole is effective in ovulation stimulation.It might be helpful in reduction of multiple pregnancy.The change of androgen induced by letrozole might adversely influence the pregnancy rate in women with PCOS.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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Cited By Count: 1
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