Title: Effects of hypertonic saline solution on plasma S100 protein in pigs undergoing cardiopulmonary bypass
Abstract: Objective To observe the effects of 7.5% hypertonic saline on plasma S100 protein in pigs undergoing cardiopulmonary bypass(CPB),and investigate the feasibility of its protective effect against cerebral injury.Methods Twenty-four 15-16 kg healthy pigs aged 6 to 8 weeks old were randomly divided into hypertonic saline group(group H) and control group(group C) with 12 pigs each.In group H 4 ml/kg 7.5% hypertonic saline was given at 15 min before CPB while in group C normal saline was given instead of hypertonic saline.After anesthesia,all animals underwent 90 min moderate hypothermic CPB.Blood samples were taken from femoral artery before CPB(T0),at 45 min during CPB(T1),the end of CPB(T2),1 h(T3)and 5 h(T4)after CPB for determination of plasma S100 protein and K+,Na+ and Cl-concentrations.Results Compared to T0,the plasma S100 protein was significantly increased at T1-T4 in the two groups(P0.01).The S100 protein of group H was significantly reduced at T1-T4 compared to that of group C(P0.05 or P0.01).Compared to T0,plasma K+ concentrations of group H was significantly high at T2,T4(P0.01),it was also more high than that of group C at T1,T3(P0.05 or P0.01).Compared to T0 and group C,plasma Na+ and Cl-concentrations of group H significantly rised at T1~T4(P0.01),but remained within normal range.Conclusion Small dose of 7.5% hypertonic saline can reduce S100 protein in pigs undergoing CPB,indicating its protective effect against the cerebral injury induced by CPB.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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