Title: Effects of astragalus injection on cerebral glucose metabolism and lactate concentration in patients undergoing cardiac operation
Abstract: Objective To investigate the effects of astragalus injection on cerebral glucose metabolism and lactate concentration in patients undergoing cardiac valve replacement with cardiopulmonary bypass (CPB). Methods 30 patients scheduled for valve replacement were randomly divided into two groups: astragalus injection group ( group A ) and control group ( group B). Anesthesia induction and maintenance were same in two groups. In group A, astragalus injection 20ml was given i.v. after induction of anesthesia. In group B normal saline was given instead of astragalus injection. The blood samples were collected from jugular bulb before injection(T1), at the moment of 33℃ cooling(T2),stable hypothermic duration ( T3 ), 33℃ rewarming(T4),0.5 h(T5),2 h ( T6 ) after CPB for determination of arterial and jugular bulb blood glucose, utilization of glucose[G (a-v)] and extraction of lactate ( Lac ). Results At points ofT2, T3, T5, T6 G (a-v) in two groups was markedly lower than those at T1 ( P<0.05 ). At points of T3, T6 G( a-v) was significantly higher in group A than that in group B ( P<0.05 ).The level of Lac increased after beginning of CPB and reached peak value at T5. At points of T4, T5, T6, The level of Lac was significantly lower in group A than that in group B (P<0.05 ).Conclusion Astragalus injection may improve cerebral glucose utilization ,and decrease the extraction of lactate.
Key words:
Astragalus injection; Cardiopulmonary bypass; Cerebral; Glucose
Publication Year: 2011
Publication Date: 2011-03-15
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot